Category Archives: Waste and pollution

November 6, 2019

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Today’s Digest features a large study on the evolution of diet and microbiota in African animals, a review on how diet can alter gut microbiota to fight infectious diseases, and we might reverse specific antibiotic resistance by removing those antibiotics in the environment. Enjoy!

General microbiology

Letter to the Editor: A conceptual framework for the phylogenetically constrained assembly of microbial communities – Daniel Aguirre de Cárcer – Microbiome

Review: The engineering of spatially linked microbial consortia – potential and perspectives – Sami Ben Said et al. – Current Opinion in Biotechnology

Preprint: Selection of representative genomes for 24,706 bacterial and archaeal species clusters provide a complete genome-based taxonomy – Donovan H. Parks et al. – bioRxiv

Antimicrobial resistance

** Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion – Anett Dunai et al. – eLife

Human respiratory microbiome

Interplay between host-microbe and microbe-microbe interactions in cystic fibrosis – Catherine R. Armbruster et al. – Journal of Cystic Fibrosis

Human gut microbiome

Review: Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art – Marilena Durazzo et al. – Journal of Clinical Medicine

Identification of a Shared Microbiomic and Metabolomic Profile in Systemic Autoimmune Diseases – Chiara Bellocchi et al. – Journal of Clinical Medicine

Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity – Robert C. Kaplan et al. – Genome Biology

Food microbiome

Comparison of microbial communities and physiochemical characteristics of two traditionally fermented vegetables – Qianqian Guan et al. – Food Research International

Animal experiments

** Review: Diet–microbiome–disease: Investigating diet’s influence on infectious disease resistance through alteration of the gut microbiome – Erica V. Harris et al. – PLoS Pathogen

Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure – Qianxu Wang et al. – Journal of Agricultural and Food Chemistry

Animal microbiome

** Covariation of diet and gut microbiome in African megafauna – Tyler R. Kartzinel et al. – PNAS

Press: Study of African animals illuminates links between environment, diet and gut microbiome – Brown University – Phys.org

Plant, root and soil microbiome

Interactive Effects of Nitrogen-Fixing Bacteria Inoculation and Nitrogen Fertilization on Soybean Yield in Unfavorable Edaphoclimatic Environments – Carlos Felipe dos Santos Cordeiro & Fábio Rafael Echer – Scientific Reports

Impacts of Maize Domestication and Breeding on Rhizosphere Microbial Community Recruitment from a Nutrient Depleted Agricultural Soil – Vanessa L. Brisson et al. – Scientific Reports

Microbial communities and soil chemical features associated with commercial production of the medicinal mushroom Ganoderma lingzhi in soil – Le-Qin Ke et al. – Scientific Reports

Feasibility of bioleaching of heavy metals from sediment with indigenous bacteria using agricultural sulfur soil conditioners – Chuncheng Wu et al. – Science of the Total Environment

Land management and microbial seed load effect on rhizosphere and endosphere bacterial community assembly in wheat – Tim H. Mauchline et al. – Frontiers in Microbiology

Water and extremophile microbiome

Comparative metagenomic analysis of microbial taxonomic and functional variations in untreated surface and reclaimed waters used in irrigation applications – Jessica Chopyk et al. – Water Research

Strong seasonality in arctic estuarine microbial food webs – Colleen T. Kellogg et al. – Frontiers in Microbiology

Evaluation of degradation behavior over tetracycline hydrochloride by microbial electrochemical technology: Performance, kinetics, and microbial communities – Xinhong Peng et al. – Ecotoxicology and Environmental Safety

Groundwater microbial communities and their connection to hydrochemical environment in Golmud, Northwest China – Liang Guo et al. – Science of the Total Environment

Performance of enhanced anaerobic digestion with different pyrolysis biochars and microbial communities – Ruixia Shen et al. – Bioresource Technology

Technology

Optimizing sequencing protocols for leaderboard metagenomics by combining long and short reads – Jon G. Sanders et al. – Genome Biology

Bioinformatics

Microbiota analysis optimization for human bronchoalveolar lavage fluid – Pierre H. H. Schneeberger et al. – Microbiome

The PATRIC Bioinformatics Resource Center: expanding data and analysis capabilities – James J Davis et al. – Nucleic Acids Research

Microbes in the news

Gut microbiome of premature babies is associated with stunted growth – EurekAlert!

Shark Skin Microbiome Protects Wounds From Infection – SciTechDaily

Fiber-rich diet eases son’s asthma, launches professor’s interdisciplinary microbiome research – Jeff Dodge – Colorado State University

Researchers identify certain gut bacteria that may be involved in causing bowel cancer – University of Bristol

Some gut bacteria may increase bowel cancer risk, research suggests – Nicola Davis – The Guardian

Certain Gut Bacteria May Contribute to Bowel Cancer – Technnology Networks

China Approves Alzheimer’s Treatment that Targets the Microbiome – Kerry Grens – The Scientist

Microbes on the market

Loop Genomics launches long-read Microbiome sequencing service at short-read price – Loop Genomics – PR Newswire

October 23, 2019

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A rich Digest today featuring the “Prime Editing” invented by the David R. Liu lab, which promises to correct 89% of point mutations, an ultra-deep metagenomic study of phages in aquatic systems and strain level interaction between bacteria and plants. Enjoy!

General microbiology

** Search-and-replace genome editing without double-strand breaks or donor DNA – Andrew V. Anzalone et al. – Nature

Resolving a piece of the archaeal lipid puzzle – Ann Pearson – PNAS

Antimicrobial resistance

Commentary: Surveillance and monitoring of antimicrobial resistance: limitations and lessons from the GRAM project – Jesse Schnall et al. – BMC Medicine

Preprint: In vitro Efficacy of Novel Glucan Synthase Inhibitor, Ibrexafungerp (SCY-078), Against Multidrug- and Pan-resistant Candida auris Isolates from the Outbreak in New York – Yan Chun Zhu et al. – bioRxiv
https://www.biorxiv.org/content/10.1101/811182v1.abstract

Review: Proteomics approach to understand bacterial antibiotic resistance strategies – Bo Peng et al. – Expert Review of Proteomics

Human oral microbiome

Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) – R.T. Demmer et al. – Journal of Dental Research

Human gut microbiome

Review: Systems biology perspective for studying the gut microbiota in human physiology and liver diseases – Ozlem Altay et al. – EBioMedicine

Review: Intestinal microbiota and colorectal carcinoma: Implications for pathogenesis, diagnosis, and therapy – Ana Montalban-Arques & Michael Scharl – EBioMedicine

Perspective: Carbohydrate-based Prebiotics in Targeted Modulation of Gut Microbiome – Ka-Lung Lam & Peter Chi Keung Cheung – Journal of Agricultural and Food Chemistry

Metabolomics

Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics – Xiaoling Zang et al. – Journal of Proteome Research

Food microbiome

Peer pressure: Evolutionary responses to biotic pressures in wine yeasts – C. G. Conacher et al. – FEMS Yeast Research

Animal experiments

Disruption of gut integrity and permeability contributes to enteritis in a fish-parasite model: a story told from serum metabolomics – Ariadna Sitjà-Bobadilla et al. – Parasites & Vectors

Animal microbiome

Estimating the burden of dengue and the impact of release of wMel Wolbachia-infected mosquitoes in Indonesia: a modelling study – Kathleen M. O’Reilly et al. – BMC Medicine

Plant, root and soil microbiome

Preprint: Insights into the desert living skin microbiome: geography, soil depth, and crust type affect biocrust microbial communities and networks in Mojave Desert, USA – Nuttapon Pombubpa et al. – bioRxiv

** Metabolites in the root exudates of groundnut change during interaction with plant growth promoting rhizobacteria in a strain-specific manner – Sravani Ankati & Appa Rao Podile – Journal of Plant Physiology

Environmental and biotic drivers of soil microbial β-diversity across spatial and phylogenetic scales – Loïc Chalmandrier et al. – Ecography

Soil hydrology drives ecological niche differentiation in a native prairie microbiome – James S Griffin et al. – FEMS Microbiology Ecology

Consistent host and organ occupancy of phyllosphere bacteria in a community of wild herbaceous plant species – Julien Massoni et al. – The ISME Journal

Effect of aridity and dune type on rhizosphere soil bacterial communities of Caragana microphylla in desert regions of northern China – Jiangli Gao et al. – PLoS One

Rhizosphere bacterial community in watermelon-wheat intercropping was more stable than in watermelon monoculture system under Fusarium oxysporum f. sp. niveum invasion – Hongjie Yu et al. – Plant and Soil

Phosphorus-acquisition strategies of canola, wheat and barley in soil amended with sewage sludges – C. Nobile et al. – Scientific Reports

Water and extremophile microbiome

Distinctive microbial communities in subzero hypersaline brines from Arctic coastal sea ice and rarely sampled cryopegs – Zachary S. Cooper et al. – FEMS Microbiology Ecology

Performance and microbial communities of different biofilm membrane bioreactors with pre-anoxic tanks treating mariculture wastewater – Huining Zhang et al. – Bioresource Technology

Do organic substrates drive microbial community interactions in Arctic snow? – Benoît Bergk Pinto et al. – Frontiers in Microbiology

Genomic signatures for sedimentary microbial utilization of phytoplankton detritus in a fast-flowing estuary – Mariya W. Smit et al. – Frontiers in Microbiology

pH control and microbial community analysis with HCl or CO2 addition in H2-based autotrophic denitrification – Wei Xing et al. – Water Research

Extremophilic nitrite-oxidizing Chloroflexi from Yellowstone hot springs – Eva Spieck et al. – The ISME Journal

Phages and viruses

** Phage-centric ecological interactions in aquatic ecosystems revealed through ultra-deep metagenomics – Vinicius S. Kavagutti et al. – Microbiome

Review: Phage Therapy with a Focus on the Human Microbiota – Sharita Divya Ganeshan & Zeinab Hosseinidoust – Antibiotics

Technology

Preprint: Gene copy normalization of the 16S rRNA gene cannot outweigh the methodological biases of sequencing – Robert Starke & Daniel Morais – bioRxiv

Review: Third generation sequencing in the clinical laboratory: Exploring the advantages and challenges of nanopore sequencing – Lauren M. Petersen et al. – Journal Clinical Microbiology

Microbes in the news

Which foods are beneficial for a healthy gut microbiome? – Ana Sandoiu – Medical News Today

Microbiome: Untapped source of novel antimicrobials – Delthia Ricks – Medical Xpress

The Problem With Labeling Gut Troubles ‘Dysbiosis’ – Elizabeth Preston – Undark

Bacteria for beauty: why you need to start thinking about your skin microbiome – Hannah Ebelthite – Telegraph

Research Finds These Mediterranean Diet Foods Protect The Gut Microbiome – Jamie Schneider – Mind Body Green

Are undiscovered antibiotics ‘silently waiting’ in our own bodies? Researchers scour microbiome for helpful genes – Shelly Fan – Genetic Literacy Project

Reprogramming the microbiome: Antara Lifesciences targets the human health space with dual targeted formulation – Tingmin Koe – Food Navigator Asia

Transient and long-term disruption of gut microbes after antibiotics – Jeff Hansen – UAB News

Microbes on the market

Microba, Psomagen Partner to Launch Microbiome Test in US – GenomeWeb

October 16, 2019

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Happy Wednesday! Today’s digest includes the human gut virome, microbiome recovery after antibiotics, and the fungi growing on museum skeletons. Enjoy!

Pregnancy and early life

The vaginal microbial communities of healthy expectant Brazilian mothers and its correlation with the newborn’s gut colonization – Dobbler – World Journal of Microbiology and Biotechnology

Human skin microbiome

In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria – Blaskovich – Scientific Reports

Human gut microbiome

Review: The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific – Shkoporov – Cell Host & Microbe

Review: Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System – Yue – Microorganisms

Individualized recovery of gut microbial strains post antibiotics – Koo – npj Biofilms and Microbiomes

Animal experiments

Depletion of dietary aryl hydrocarbon receptor ligands alters microbiota composition and function – Brawner – Scientific Reports

Rat H1 parvovirus infection leads to alterations in gut microbiota – Xiang – Pathogens and Disease

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease – Bordoni – PLoS One

The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis – Kushkevych – Journal of Clinical Medicine

Plant, root, and soil microbiome

Spatial gradients in the characteristics of soil-carbon fractions are associated with abiotic features but not microbial communities – Sengupta – Biogeosciences

Water and extremophile microbiome

Diversity, Distribution, and Ecology of Fungi in the Seasonal Snow of Antarctica – Menezes – Microorganisms

Interaction and assembly processes of abundant and rare microbial communities during a diatom bloom process – Zhang – Environmental Microbiology

Built environment

Changes in the Bacterioplankton Community Structure from Southern Gulf of Mexico During a Simulated Crude Oil Spill at Mesocosm Scale – Valencia-Agami – Microorganisms

Increased loading leads to convergence of microbial communities and high methane yield in adapted anaerobic co-digesters – Wang – Water Research

Skeleton bones in museum indoor environments offer niches for fungi and are affected by weathering and deposition of secondary minerals – Pinzari – Environmental Microbiology

Bioinformatics

Species abundance information improves sequence taxonomy classification accuracy – Kaehler – Nature Communications

October 9, 2019

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Today’s Digest includes plenty of human gut microbiome papers, and plant, soil, water microbiome papers. Today features a major expansion of human gut MAGs, evolution of human gut microbiome compared with apes, and how soil microbiome affects climate change and vice versa. A potentially revolutionary technology promises to finally bring microbiome dark matters into daylight, and don’t forget to check out our own Elies Bik’s excellent work on exposing scientific fraud! Enjoy.

General microbiology

Tradeoffs in hyphal traits determine mycelium architecture in saprobic fungi – Anika Lehmann et al. – Scientific Reports

Review: Nature’s recyclers: anaerobic microbial communities drive crude biomass deconstruction – Stephen P Lillington et al. – Current Opinion in Biotechnology

Review: Microbial functional diversity: From concepts to applications – Arthur Escalas e t al. – Ecology and Evolution

Antimicrobial resistance

Preprint: Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: An inter-laboratory study – Ronan M Doyle et al. – bioRxiv

Human gut microbiome

** Preprint: A unified sequence catalogue of over 280,000 genomes obtained from the human gut microbiome – Alexandre Almeida et al. – bioRxiv

** Convergence of human and Old World monkey gut microbiomes demonstrates the importance of human ecology over phylogeny – Katherine R. Amato et al. – Genome Biology

Press: New research furthers understanding about what shapes human gut microbiome – EurekAlert!

Review: Sodium, Hypertension, and the Gut: Does the Gut Microbiota Go Salty? – Katarina Smiljanec & Shannon L. Lennon – American Journal of Physiology-Heart and Circulatory Physiology

Tea Compounds and the Gut Microbiome: Findings from Trials and Mechanistic Studies – Timothy Bond & Emma Derbyshire – Nutrients

Fecal microbiota and metabolites are distinct in a pilot study of pediatric Crohn’s disease patients with higher levels of perceived stress – Laura M. Mackner et al. – Psychoneuroendocrinology

Review: The Gut Microbiota in Celiac Disease and probiotics – Richa Chibbar & Levinus A. Dieleman – Nutrients

Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both? – Gregg J Silverman et al. – Current Opinion in Immunology

Review: The Multiple Sclerosis Gut Microbiota: A Systematic Review – Ali Mirza et al. – Multiple Sclerosis and Related Disorders

Animal experiments

Oolong tea polyphenols ameliorate circadian rhythm of intestinal microbiome and liver clock genes in mouse model – Tongtong Guo et al. – Journal of Agricultural and Food Chemistry

Review: Caenorhabditis elegans: a model to understand host–microbe interactions – Arun Kumar et al. – Cellular and Molecular Life Sciences

Animal microbiome

Wildlife-microbiome interactions and disease: exploring opportunities for disease mitigation across ecological scales – Candace L. Williams et al. – Drug Discovery Today: Disease Models

Plant, root and soil microbiome

Soil Microbial Communities Involved in Reductive Dissolution of Arsenic from Arsenate-laden Minerals with Different Carbon Sources – Shigeki Yamamura et al. – Environmental Science & Technology

Volatile‐mediated antagonism of soil bacterial communities against fungi – Xiaogang Li et al. – Environmental Microbiology

Interactions between soybean, Bradyrhizobium japonicum and Soybean mosaic virus: the effects depend on the interaction sequence – Sofía Andreola et al. – Functional Plant Biology

New insights into the responses of soil microorganisms to polycyclic aromatic hydrocarbon stress by combining enzyme activity and sequencing analysis with metabolomics – Xiaona Li et al. – Environmental Pollution

Understanding the phyllosphere microbiome assemblage in grape species (Vitaceae) with amplicon sequence data structures – Prashant Singh et al. – Scientific Reports

** Review: Soil microbiomes and climate change – Janet K. Jansson & Kirsten S. Hofmockel – Nature Reviews Microbiology

Variation in pickleweed root-associated microbial communities at different locations of a saline solid waste management unit contaminated with petroleum hydrocarbons – Abdur Rahim Khan et al. – PLoS One

Plant-plant competition influences temporal dynamism of soil microbial enzyme activity – E. J. Schofield et al. – Soil Biology and Biochemistry

Comparison of microphototrophic communities living in different soil environments in the High Arctic – Ekaterina Pushkareva et al. – Frontiers in Ecology and Evolution

Water and extremophile microbiome

Novel facultative Methylocella strains are active methane consumers at terrestrial natural gas seeps – Muhammad Farhan Ul Haque et al. – Microbiome

Selective bacterial colonization processes on polyethylene waste samples in an abandoned landfill site – Edoardo Puglisi et al. – Scientific Reports

Variation in pickleweed root-associated microbial communities at different locations of a saline solid waste management unit contaminated with petroleum hydrocarbons – Abdur Rahim Khan et al. – PLoS One

Bacterial and Fungal Diversity Inside the Medieval Building Constructed with Sandstone Plates and Lime Mortar as an Example of the Microbial Colonization of a Nutrient-Limited Extreme Environment (Wawel Royal Castle, Krakow, Poland) – Magdalena Dyda et al. – Microorganisms

Evaluating the effect of biochar on mesophilic anaerobic digestion of waste activated sludge and microbial diversity – Bo Wu et al. – Bioresource Technology

Species-specific differences in the microbiomes and organic exudates of crustose coralline algae influence bacterioplankton communities – Zachary A. Quinlan et al. – Frontiers in Microbiology

A global comparison of the bacterial communities of bilge water, boat surfaces, and external port water – Laura G. Schaerer et al. – Applied and Environmental Microbiology

Microbes in space

Simulated manned Mars exploration: effects of dietary and diurnal cycle variations on the gut microbiome of crew members in a controlled ecological life support system – Hai-Sheng Dong et al. – PeerJ

Technology

** Targeted isolation and cultivation of uncultivated bacteria by reverse genomics – Karissa L. Cross et al. – Nature Biotechnology

Bioinformatics

Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases – Ole K Tørresen et al. – Nucleic Acids Research

Microbes in the news

Bill Gates thinks understanding the body’s microbiome will help solve malnutrition – Katie Palmer – Quartz

Press for yesterday’s article: Unlocking CRISPR’s Potential To Alter the Microbiome – Technology Networks

Press for yesterday’s article: New Study Finds CRISPR May Be The Secret To Improving Gut Health – Gretchen Lidicker – Mind Body Green

Drug Metabolism and Microbiome – Maryam Azizi – News Medical

The Gut-Lupus Link: How Gut Bacteria May Impact Disease Development and Activity – Lupus Foundation of America

Microbes on the market

BASF and Biomillenia Join Forces in Microbiome Research to Promote Healthy Skin – Business Wire

Non-microbiology pick

** Our own Elies Bik is featured in this Dutch report on exposing scientific fraud, and see a Google translated version here.

October 5, 2019

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This weekend, read about how cooking food modifies the microbiome, how bacteria ‘strip off’ to evade antibiotics, and more. Check out an interesting pilot study looking at potential inclusion and exclusion criteria of donors for safe vaginal microbiota transplant. Enjoy!

Events

Bioinformatics for the Microbiome Symposium 2019, Stanford University, Monday October 28.
Some tickets are still available!

General microbiome

Mobile phones as fomites for potential pathogens in hospitals: microbiome analysis reveals hidden contaminants – Rebecca Simmonds – Journal of Hospital Infection

Review: Microbiomes as sources of emergent host phenotypes – J. B. Lynch and E. Y. Hsiao – Science

Vaginal microbiome

*Conceptual Design of a Universal Donor Screening Approach for Vaginal Microbiota Transplant – Kevin DeLong – Frontiers in Cellular and Infection Microbiology

Highly diverse anaerobe-predominant vaginal microbiota among HIV-infected pregnant women in Zambia – Joan T. Price – PlosOne

Urinary microbiome

*Possible role of L-form switching in recurrent urinary tract infection – Katarzyna M. Mickiewicz – Nature Communications

Aerococcus urinae and Globicatella sanguinis Persist in Polymicrobial Urethral Catheter Biofilms Examined in Longitudinal Profiles at the Proteomic Level – Yanbao Yu – Biochemistry Insights

Gut microbiome

*Cooking shapes the structure and function of the gut microbiome – Rachel N. Carmody – Nature Microbiology

Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma – Wen Fong Ooi – Gut

Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial – Selina R.Cox – Gastroenterology

Water microbiome

Trophic networks improve the performance of microbial anodes treating wastewater – Christin Koch – npj Biofilms and Microbiomes

Application of a novel molecular technique to characterise the effect of settling on microbial community composition of activated sludge – Luong N.Nguyen – Journal of Environmental Management

Bacterial diversity in Icelandic cold spring sources and in relation to the groundwater amphipod Crangonyx islandicus – Ragnhildur Guðmundsdóttir – PlosOne

Animal microbiome

Looking like the locals – gut microbiome changes post-release in an endangered species – Rowena Chong – Animal microbiome

Animal experiment

Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome – Pablo Arroyo – PlosOne

Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection – Ashley D. Smith – PlosOne

Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model – Yoshitomo Morinaga – PlosOne

Plant microbiome

Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae) – Suresh J. Gawande – PlosOne

Food

Comparison of the microbial composition of African fermented foods using amplicon sequencing – Maria Diaz – Scientific Reports

The impact of grape processing and carbonic maceration on the microbiota of early stages of winemaking – Raffaele Guzzon – Journal of Applied Microbiology

Fungi

Phyllosphere Fungal Communities of Plum and Antifungal Activity of Indigenous Phenazine-Producing Pseudomonas synxantha Against Monilinia laxa – Tamara Janakiev – Frontiers in Microbiology

Microbial communities associated with the black morel Morchella sextelata cultivated in greenhouses – Gian Maria Niccolò Benucci – PeerJ

Viruses

The gut virome in inflammatory bowel disease pathogenesis: From metagenomics to novel therapeutic approaches – Federica Ungaro – United European Gastroenterology Journal

Association of the Eukaryotic Vaginal Virome with Prophylactic Antibiotic Exposure and Reproductive Outcomes in a Subfertile Population Undergoing In Vitro Fertilization: A Prospective Exploratory Study – Ashley M. Eskew – Obstetrics and Gynaecology

Bioinformatics

ProphET, prophage estimation tool: A stand-alone prophage sequence prediction tool with self-updating reference database – João L. Reis-Cunha – PlosOne

September 23, 2019

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This Monday, check out the largest ever study of neonatal microbiomes, the study where researchers alter mouse gut microbiomes by feeding good bacteria their preferred fibers, and the study about the significant effect of antibiotics, antivirals and cofactors on the gut microbiome. Happy reading!

Pregnancy and early life

*Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth – Yan Shao – Nature

Gut microbiome

*Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans – Michael Patnode – Cell

*Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study – Matthias Willmann – BMC Biology

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus – Feng Zhu – bioRxiv

Fecal Microbiotas of Indonesian and New Zealand Children Differ in Complexity and Bifidobacterial Taxa during the First Year of Life – Blair Lawley – Applied and Environmental Microbiology

Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis – Cristina Godinho-Silva – Nature

Baseline human gut microbiota profile in healthy people and standard reporting template – Charles H. King – PlosOne

Oral microbiome

Taste perception and oral microbiota are associated with obesity in children and adolescents – Chiara Mameli – PlosOne

Urinary microbiome

The urobiome of continent adult women: a cross-sectional study – Travis Price – Obstetrics & Gynaecology

The Urinary Microbiota in Relation to the Reproductive Tract Microbiota – Fei Li – bioRxiv

Respiratory microbiome

The effects of e-cigarette vapor exposure on the transcriptome and virulence of Streptococcus pneumoniae – Kamal Bagale – bioRxiv

Water microbiome

Diversity patterns of marine heterotrophic culturable bacteria along vertical and latitudinal gradients – Isabel Sanz-Sáez – bioRxiv

Laundry wastewater and domestic sewage pilot-scale anaerobic treatment: Microbial community resilience regarding sulfide production – A.G.L. Moura – Journal of Environmental Management

Distinct responses from bacterial, archaeal and fungal streambed communities to severe hydrological disturbances – G. Gionchetta – Scientific reports

Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes – Parul Mittal – Environmental Microbiome

Plant/root/soil microbiome

Host-Associated Quantitative Abundance Profiling Reveals the Microbial Load Variation of Root Microbiome – Xiaoxuan Guo – Plant Communications

Metatranscriptomics reveals climate change effects on the rhizosphere microbiomes in European grassland – Qicheng Bei – Soil Biology and Biochemistry

Phages and viruses

Beyond cells – The virome in the human holobiont – Rodrigo García-López – Microbial cells

ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples – Ardi Tampu – PlosOne

Bioinformatics

Review: The signal and the noise – characteristics of antisense RNA in complex microbial communities – Thomas Yssing Michaelsen – bioRxiv

SuRF: a New Method for Sparse Variable Selection, with Application in Microbiome Data Analysis – Lihui Liu – arXiv

September 17, 2019

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Happy Tuesday! Today’s digest includes wastewater treatment biofilms, the microbiome during Crohn’s disease remission, and the bacteria associated with acid mine drainage. Enjoy!

Human oral microbiome

Succession of oral microbiota community as a tool to estimate postmortem interval – Dong – Scientific Reports

Human gut microbiome

Remission in Crohn’s disease is accompanied by alterations in the gut microbiota and mucins production – Magro – Scientific Reports

Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation – Ingham – Microbiome

Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) – Wu – Journal of Functional Foods

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals – Scepanovic – Microbiome

Animal experiments

Dietary Bovine Milk Exosomes Elicit Changes in Bacterial Communities in C57BL/6 Mice – Zhou – American Journal of Physiology

Microbial Metabolism Modulates Antibiotic Susceptibility within the Murine Gut Microbiome – Cabral – Cell Metabolism

Animal microbiome

Maternal vs artificial rearing shapes the rumen microbiome having minor long‐term physiological implications – Belanche – Environmental Microbiology

Plant, root, and soil microbiome

Impact of continuous Panax notoginseng plantation on soil microbial and biochemical properties – Zhang – Scientific Reports

Three Bermudagrass-suppression techniques have little effect on soil-nutrient availability and microbial communities 200 days after application – Farthing – Applied Soil Ecology

Water and extremophile microbiome

Effect of salinity on mature wastewater treatment biofilm microbial community assembly and metabolite characteristics – Wang – Science of the Total Environment

Diversity and functional profile of bacterial communities at Lancaster acid mine drainage dam, South Africa as revealed by 16S rRNA gene high-throughput sequencing analysis – Lukhele – Extremophiles

Abiotic stress resistance, plant growth promotion and antifungal potential of halotolerant bacteria from a Tunisian solar saltern – Masmoudi – Microbiological Research

Built environment

Effective removal of antibiotic resistance genes and potential links with archaeal communities during vacuum-type composting and positive-pressure composting – Fan – Journal of Environmental Science

Hydraulically Fractured Natural-Gas Well Microbial Communities Contain Genomic Halogenation and Dehalogenation Potential – Evans – Environmental Science & Technology Letters

Successional trophic complexity and biogeographical structure of eukaryotic communities in waterworks rapid sand filters – Harder – FEMS Microbiology Ecology

September 13, 2019

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In today’s edition, you’ll find a whole new textbook about microbes affecting ecosystem sustainability, reviews about phages and plant viruses, New York Times coverage of clinical trials of FMT for obesity, how to banish “manels” from scientific meetings, and microbiota-related metabolites as biomarkers of aging. Enjoy!

General microbiome
Review: Microbial invasions in terrestrial ecosystems – Madhav P. Thakur – Nature Reviews Microbiology

Preprint: Therapeutically exploring persister metabolism in bacteria – Sayed G. Mohiuddin – bioRxiv

Preprint: Delayed antibiotic exposure induces population collapse in enterococcal communities with drug-resistant subpopulations – Kelsey M Hallinen – bioRxiv

Human gut microbiome
Review: Pairing phages with their hosts in the human gut – Ursula Hofer – Nature Reviews Microbiology

Book chapter: Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging – Andrea Ticinesi – Reviews on Biomarker Studies in Aging and Anti-Aging Research

Animal microbiome
Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods – Kelly L. Bennett – PLOS One

Plant, root, soil microbiome
Book chapter: Rhizospheric Microbiome Engineering as a Sustainable Tool in Agriculture: Approaches and Challenges – Shubham Dubey – Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications

Book chapter: Dynamics of Plant Microbiome and Its Effect on the Plant Traits – Shivali Sharma – Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications

Book chapter: Microbial Diversity of the Sundarbans, the World’s Largest Tidal Mangrove Forest, and Its Bioprospects – Kaushik Biswas – Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications

Water and extremophile microbiome
Capability for arsenic mobilization in groundwater is distributed across broad phylogenetic lineages – Robert E. Danczak – PLOS One

Food microbiology
Book chapter: Microbial Diversity on Grapes and Other Fruits: Role and Significance in Fermentation – M. V. Deshpande – Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications

The Dynamics Analysis of Fungal Community Diversity During the Fermentation Process of Chinese Traditional Soybean Paste – Jingping Ge – Waste and Biomass Valorization

Phages and viruses
Review: Evolution and ecology of plant viruses – Pierre Lefeuvre – Nature Reviews Microbiology

Bioinformatics
An Integrated Approach for Efficient Multi-Omics Joint Analysis – Massimiliano S. Tagliamonte – Proceedings of the 10th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics

Techniques
Polysaccharide-based liquid storage and transport media for non-refrigerated preservation of bacterial pathogens – Janine R. Hutchison – PLOS One

Microbes in the news
Seeking an Obesity Cure, Researchers Turn to the Gut Microbiome -Anahad O’Connor – NY Times

Exclusive: Behind the front lines of the Ebola wars – Amy Maxmen – Nature

Science, publishing, and career
How to banish manels and manferences from scientific meetings – Holly Else – Nature

September 11, 2019

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Today’s Digest features a study on how antibiotic use in preterm infants might cause long-term impacts, a report on the effect of antibiotics on vaccine response, and a special issue on microbiome biology. Happy reading!

Course

Nutrition and Health: Human Microbiome – a MOOC by Clara Belzer – Gut Microbiota For Health

General microbiome

** Special Issue: Microbiome Biology – Genome Biology & BMC Biology

Editorial: Expanding the scope and scale of microbiome research – Rob Knight et al. – Genome Biology

Review: Challenges in the construction of knowledge bases for human microbiome-disease associations – Varsha Dave Badal et al. – Microbiome

Review: The Microbiome and Aging – Bianca Bana & Filipe Cabreiro – Annual Review of Genetics

Pregnancy and early life

** Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome – Andrew J. Gasparrini et al. – Nature Microbiology

Press: Prolonged antibiotic treatment may alter preterm infants’ microbiome – National Institutes of Health

Review: Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring – Marta Calatayud et al. – Trends in Endocrinology & Metabolism

Human respiratory microbiome

In vitro: In vitro evolution of Pseudomonas aeruginosa AA2 biofilms in the presence of cystic fibrosis lung microbiome members – Eva Vandeplassche et al. – Scientific Reports

Human gut microbiome

** Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans – Thomas Hagan et al. – Cell

Press: Microbiome loss from antibiotic use affects response to flu vaccine – Angela Betsaida B. Laguipo – News Medical

Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes – Elena Barengolts et al. – Microorganisms

Protocol: Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial – Sanja Vanhatalo et al. – BMJ Open

Effects of anti-H. pylori triple therapy and a probiotic complex on intestinal microbiota in duodenal ulcer – Lili Wu et al. – Scientific Reports

Cancer microbiome

Review: The Microbiome and Prostate Cancer Risk – Karen M. Wheeler & Michael A. Liss – Current Urology Reports

Press: The Microbiome and Prostate Cancer Risk – Uro Today

Profiling of lung microbiota discloses differences in adenocarcinoma and squamous cell carcinoma – Sílvia Gomes et al. – Scientific Reports

Animal experiments

Triclosan-selected host-associated microbiota perform xenobiotic biotransformations in larval zebrafish – Chelsea A Weitekamp et al. – Toxicological Sciences

Effects of theabrownin on serum metabolite and gut microbiome in rats with high-sugar diet – Suijuan Yue et al. – Food & Function

Animal microbiome

Effects of long-term starvation on health indices, gut microbiota and innate immune response of fresh water crayfish, marron (Cherax cainii, Austin 2002) – Md Javed Foysal et al. – Aquaculture

Plant, root and soil microbiome

Effects of road salt on microbial communities: Halophiles as biomarkers of road salt pollution – Wolf T. Pecher et al. – PLoS One

Conservation of the endophyte microbiome structure across two Panicum grass species – Esther Singer et al. – Frontiers in Microbiology

Characterization of Microbial Communities, Identification of Cr(VI) Reducing Bacteria in Constructed Wetland and Cr(VI) Removal Ability of Bacillus cereus – Hua Lin et al. – Scientific Reports

Review: The plant microbiome: A missing link for the understanding of community dynamics and multifunctionality in forest ecosystems – Sandhya Mishra e al. – Applied Soil Ecology

Combining irrigation scheme and phosphorous application levels for grain yield and their impacts on rhizosphere microbial communities of two rice varieties in a field trial – Yingjiao Zhang et al. – Journal of Agricultural and Food Chemistry

Soil-plant compartments affect fungal microbiome diversity and composition in grapevine – María del PilarMartínez-Diz et al. – Fungal Ecology

Water and extremophile microbiome

The fungicide azoxystrobin promotes freshwater cyanobacterial dominance through altering competition – Tao Lu et al. – Microbiome

Diel oscillation of microbial gene transcription declines with increasing depth in oligotrophic ocean waters – Alice Vislova et al. – Frontiers in Microbiology

Long term performance and dynamics of microbial biofilm communities performing sulfur-oxidizing autotrophic denitrification in a moving-bed biofilm reactor – Yan-Xiang Cui et al. – Water Research

Opportunistic pathogens and large microbial diversity detected in source-to-distribution drinking water of three remote communities in Northern Australia – Mirjam Kaestli et al. – PLoS Neglected Tropical Diseases

The diversity and biogeography of microeukaryotes in the euphotic zone of the northwestern Pacific Ocean – Peng-Fei Wu et al. – Science of the Total Environment

Comparative evaluation of three archaeal primer pairs for exploring archaeal communities in deep-sea sediments and permafrost soils – Shiping Wei et al. – Extremophiles

Characterizations of microbial diversity and machine oil degrading microbes in machine oil contaminated soil – Mengjiao Wang et al. – Environmental Pollution

Metaproteomics reveal that rapid perturbations in organic matter prioritize functional restructuring over taxonomy in western Arctic Ocean microbiomes – Molly P. Mikan et al. – The ISME Journal

Microbes in space

Space Station conditions are selective but do not alter microbial characteristics relevant to human health – Maximilian Mora et al. – Nature Communications

Phages and viruses

Preprint: European and tropical Aedes albopictus mosquito populations have similar systemic Zika virus infection dynamics – Sebastian Lequime et al. – bioRxiv

Technology

Preprint: A novel and direct mobilome approach improves the detection of larger-sized circular elements across kingdoms – Katrine Skov Alanin et al. – bioRxiv

Power production and microbial community composition in thermophilic acetate-fed up-flow and flow-through microbial fuel cells – Paolo Dessì et al. – Bioresource Technology

Microbial Interaction Network Inference in Microfluidic Droplets – Ryan H. Hsu et al. – Cell Systems

Revealing the metabolic capacity of Streblomastix strix and its bacterial symbionts using single-cell metagenomics – Sebastian C. Treitli et al. – PNAS

Bioinformatics

Fast and accurate average genome size and 16S rRNA gene average copy number computation in metagenomic data – Emiliano Pereira-Flores et al. – BMC Bioinformatics

Microbes in the news

The diet-microbiome connection in inflammatory bowel disease – University of Pennsylvania – EurekAlert!

How Bacteria Rule Over Your Body – The Microbiome – YouTube

Will Drinking Red Wine Give You A Healthier Microbiome? – Angela Dowden – American Council on Science and Health

What Role Does Bariatric Surgery Play in Altering the Gut Microbiome? – Suzanne Bujara – Endocrinology Advisor

Microbes on the market

Poised for growth: how to scale a microbiome engineering company – Embriette Hyde – SynbioBeta

September 6, 2019

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Today’s rich Digest features a report on how persister pathogens can spread antibiotic resistant plasmids, a study on how diet might alleviate Alzheimer’s, and a screen for the effect of microbiome on diabetes drug efficacy. Other highlights include the evolution and ecology of animal gut microbial communities, microbial communities in soils with radioactive contamination, and free microbiome standards by Zymo Research. Happy reading!

General microbiology

The horizontal gene transfer of Agrobacterium T-DNAs into the series Batatas (Genus Ipomoea) genome is not confined to hexaploid sweetpotato – Dora G. Quispe-Huamanquispe et al. – Scientific Reports

Simulations reveal challenges to artificial community selection and possible strategies for success – Li Xie et al. – PLoS Biology

Primer: Artificially selecting microbial communities: If we can breed dogs, why not microbiomes? – Flor I. Arias-Sánchez et al. – PLoS Biology

Antimicrobial resistance

** Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut – Erik Bakkeren et al. – Nature

Pregnancy and early life

Prenatal antibiotics exposure and the risk of autism spectrum disorders: A population-based cohort study – Amani F. Hamad et al. – PLoS One

Visualization of microbes by 16S in situ hybridization in term and preterm placentas without intraamniotic infection – Maxim D. Seferovic et al. – AJOG

Fetal exposure to the maternal microbiota in humans and mice – Noelle Younge et al. – JCI Insight

Fungi form interkingdom microbial communities in the primordial human gut that develop with gestational age – Kent A. Willis et al. – FASEB J.

Human oral and esophageal microbiome

In vitro: The inhibitory effect of quaternary ammonium salt on bacteria in root canal – Sanjay Kumar Tiwari et al. – Scientific Reports

Alterations to the Esophageal Microbiome Associated with Progression from Barrett’s Esophagus to Esophageal Adenocarcinoma – Erik J. Snider et al. – Cancer Epidemiology, Biomarkers & Prevention

Human respiratory microbiome

Review: The microbiome in bronchiectasis – Hollian Richardson et al. – European Respiratory Review

Human gut microbiome

Gut microbiota alterations associated with reduced bone mineral density in older adults – Mrinmoy Das et al. – Rheumatology

Press: Confounding factors in the effect of gut microbiota on bone density – Rajeev Aurora – Rheumatology

Characterization of Proximal Small Intestinal Microbiota in Patients With Suspected Small Intestinal Bacterial Overgrowth – Andrea S. Shin et al. – Clinical and Translational Gastroenterology

Gut microbiota shifts in patients with gastric cancer in perioperative period – Liang, Weiren et al. – Medicine

Human gut-microbiome-brain axis

** Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment – Ravinder Nagpal et al. – EBioMedicine

Press: Diet’s effect on gut bacteria could play role in reducing Alzheimer’s risk – Science Daily

Systemic review and meta-analysis of alcohol induced gut dysbiosis and the resulting behavioral impact – Nayab Qamar et al. – Behavioral Brain Research

Review: The Microbiota-Gut-Brain Axis – John F. Cryan et al. – Physiological Reviews

Human multi-site microbiome

Prosthetic joint infections present diverse and unique microbial communities using combined whole-genome shotgun sequencing and culturing methods – Abigail A. Weaver et al. – Journal of Medical Microbiology

Metabolomics

Metabolic switches from quiescence to growth in synchronized Saccharomyces cerevisiae – Jinrui Zhang et al. – Metabolomics

Animal experiments

Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model – Jared D. Hoffman et al. – PLoS One

Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs – Donghyun Shin et al. – PLoS One

Effects of antibacterial peptides on rumen fermentation function and rumen microorganisms in goats – Zhihua Ren et al. – PLoS One

** Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy – Rosina Pryor et al. – Cell

Press: An Elegan(t) screen shows how the microbiome improves drug efficacy – MRC Research News

Rat: Variation in the gut microbial community is associated with the progression of liver regeneration – Qiongling Bao et al. – Hepatology Research

Animal microbiome

The Pacific harbor seal gut microbiota in Mexico: Its relationship with diet and functional inferences – Arlette Pacheco-Sandoval et al. – PLoS One

Gut microbiota features associated with Clostridioides difficile colonization in puppies – Alexander S. F. Berry et al. – PLoS One

Gut microbiota and their putative metabolic functions in fragmented Bengal tiger population of Nepal – Dibesh Karmacharya et al. – PLoS One

Cadmium and selenate exposure affects the honey bee microbiome and metabolome, and bee-associated bacteria show potential for bioaccumulation – Jason A. Rothman et al. – Applied and Environmental Microbiology

* Review: Evolutionary and Ecological Consequences of Gut Microbial Communities – Nancy A. Moran et al. – Annual Reviews of Ecology, Evolution & Systemactics

Defining the distinct skin and gut microbiomes of the northern pike (Esox lucius) – Elizabeth M. Reinhart et al. – Frontiers in Microbiology

Predicting the unpredictable: How host specific is the mycobiota of bark and ambrosia beetles? – Kirsten E. Miller et al. – Fungal Ecology

Plant, root and soil microbiome

Preprint: The microbiome as a biosensor: functional profiles elucidate hidden stress in hosts – Avihai Zolti et al. – bioRxiv

Soil indigenous microbiome and plant genotypes cooperatively modify soybean rhizosphere microbiome assembly – Fang Liu et al. – BMC Microbiology

* Community structure and functional genes in radionuclide contaminated soils in Chernobyl and Fukushima – Carolina Hoyos-Hernandez et al. – FEMS Microbiology Letters

Microalgae and phototrophic purple bacteria for nutrient recovery from agri-industrial effluents: Influences on plant growth, rhizosphere bacteria and putative carbon and nitrogen cycling genes – Somayeh Zarezadeh et al. – Frontiers in Plant Science

Shifts and recovery of soil microbial communities in a 40-year field trial under mineral fertilization – Jiří Čuhel et al. – Pedobiologia

Water and extremophile microbiome

Identification of soluble microbial products (SMPs) from the fermentation and methanogenic phases of anaerobic digestion – C. Kunacheva et al. – Science of the Total Environment

Review: Microbial mercury methylation in the cryosphere: Progress and prospects – Prakriti Sharma Ghimire et al. – Science of the Total Environment

Rapid Colonization of Uranium Mining-Impacted Waters, the Biodiversity of Successful Lineages of Phytoplankton Extremophiles – Beatriz Baselga-Cervera – Microbial Ecology

Relationship between microbial community and environmental conditions in a constructed wetland system treating greywater – F.S.Bernardes et al. – Ecological Engineering

Built environment microbiome

Microbial Exchange via Fomites and Implications for Human Health – Brent Stephens et al. – Current Pollution Reports

Phages and viruses

Faecal Virome Analysis of Wild Animals from Brazil – Matheus A. Duarte et al. – Viruses

Bioinformatics

Accurate estimation of microbial sequence diversity with Distanced – Timothy J Hackmann – Bioinformatics

Microbes in the news

Researchers reveal how bacteria behind hospital infections block out antibiotics – Dumbarton and Vale of Leven Reporter

Using mouthwash could reduce benefits of exercise – Dumbarton and Vale of Leven Reporter

* A comprehensive catalogue of human digestive tract bacteria – Anne Trafton – MIT News

No poop required: Researchers devise blood test for gut microbiome diversity using data from defunct startup Arivale – James Thorne – Geek Wire

* Zymo Research Distributes Free Microbiome Standards and Controls – PR Newswire

Top List: Trending in microbiome: From comprehensive culture workflows, to novel biotherapeutics, and microbial characterization – Select Science

APC Researcher Awarded Global Grant For Gut Health – APC Microbiome Ireland

* Poop-testing startup uBiome was once valued at $600 million by Silicon Valley’s top VCs. It just filed for bankruptcy – Erin Brodwin & Emma Court – Business Insider

Gut feeling: How a healthy microbiome helps beat stress and lift mood – Scott Anderson – New Scientist

HLA Alleles With Risk for Ankylosing Spondylitis, Rheumatoid Arthritis Affect Gut Microbiome – Hannah Dellabella – Rheumatology Advisor

How the microbiome movement can be beneficial to you overall health – KUSI Newsroom

No microbiome is an island, survey reveals – Elizabeth Pennisi – Science

Microbes on the market

Metagenomic Analysis of the Human Microbiome – Technology Networks

Update note: Added additional pregnancy/neonatal microbiome papers – Sept 15, @kentmd