Human Skin Microbiome

A very preliminary collection of skin microbiome papers. Links to PMC (Open Access) when available. Focus on review papers. Suggestions for more papers are welcome by leaving a comment. Created September 2016, updated February 2018. Also see Wound Microbiome page.

Skin microbiome in health, research papers

Human Skin Is the Largest Epithelial Surface for Interaction with Microbes – Richard L.Gallo – Journal of Investigative Dermatology – June 2017

Semi-automated quantitative analysis of the human skin microbiome diversity – Chihiro Kumagai – Journal of Dermatological Science – May 2017

Experimental metagenomics and ribosomal profiling of the human skin microbiome – Pamela Ferretti – Experimental Dermatology – January 2017

Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform – Madhura Castelino – BMC Microbiology – January 2017

Temporal Stability of the Human Skin Microbiome – Julia Oh – Cell – May 2016

Body Site Is a More Determinant Factor than Human Population Diversity in the Healthy Skin Microbiome – Guillermo I. Perez Perez – PLOS ONE – April 2016

Skin Microbiome Surveys Are Strongly Influenced by Experimental Design – Jacquelyn S. Meisel et al. – Journal of Investigative Dermatology – March 2016

Research Techniques Made Simple: Bacterial 16S Ribosomal RNA Gene Sequencing in Cutaneous Research – Jay-Hyun Jo – Journal of Investigative Dermatology – March 2016

Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin – Guangxi Wu – PLOS ONE – November 2015

Open Access via PMCBiogeography and individuality shape function in the human skin metagenome – Julia Oh, Allyson L. Byrd, Clay Deming, Sean Conlan, NISC Comparative Sequencing Program, Heidi H. Kong & Julia A. Segre – Nature – October 2014

Topographic diversity of fungal and bacterial communities in human skin – Keisha Findley, Julia Oh, Joy Yang et al. – Nature – May 2013

Structure, function and diversity of the healthy human microbiome – The Human Microbiome Project Consortium – Nature – 2012

Moving pictures of the human microbiome – J Gregory Caporaso – Genome Biology – 2011

Bacterial Community Variation in Human Body Habitats Across Space and Time – Elizabeth K. Costello, Christian L. Lauber, Micah Hamady, Noah Fierer, Jeffrey I. Gordon, and Rob Knight – Science – November 2009

Topographical and Temporal Diversity of the Human Skin Microbiome – Elizabeth A. Grice, Heidi H. Kong, Sean Conlan, Clayton B. Deming, Joie Davis, Alice C. Young, NISC Comparative Sequencing Program, Gerard G. Bouffard, Robert W. Blakesley, Patrick R. Murray, Eric D. Green, Maria L. Turner, and Julia A. Segre – Science – May 2009

The influence of sex, handedness, and washing on the diversity of hand surface bacteria – Noah Fierer et al. PNAS – November 2008

Molecular analysis of human forearm superficial skin bacterial biota – Zhan Gao, Chi-hong Tseng, Zhiheng Pei, and Martin J. Blaser – PNAS – February 2007

Detection of potentially novel bacterial components of the human skin microbiota using culture- independent molecular profiling – Itaru Dekio et al. – J Med Microbiology 2005

Skin microbiome in health, review papers

The human skin microbiome – Allyson L. Byrd – Nature Reviews Microbiology – January 2018

Performing Skin Microbiome Research: A Method to the Madness – Heidi H. Kong – Journal of Investigative Dermatology – March 2017

Factors shaping the composition of the cutaneous microbiota – K. Szabó – British Journal of Dermatology – August 2016

The influence of skin microorganisms on cutaneous immunity – Yasmine Belkaid – Nature Reviews Immunology – May 2016

Microbial Ecology of the Human Skin – Anthony M. Cundell – Microbial Ecology – May 2016

The intersection of microbiome and host at the skin interface: genomic- and metagenomic-based insights – Elizabeth A. Grice – Genome Research – October 2015

Review of human hand microbiome research – Sarah L. Edmonds-Wilson – Journal of Dermatological Science – July 2015

Dialogue between skin microbiota and immunity – Yasmine Belkaid, Julia A. Segre – Science – 2015

The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease – Elizabeth A. Grice – Semin Cutan Med Surg – May 2014

The skin microbiome – Elizabeth A. Grice and Julia A. Segre – Nat Rev Microbiol – April 2011

Skin microbiome in disease


Association of Disease Severity With Skin Microbiome and Filaggrin Gene Mutations in Adult Atopic Dermatitis – Maja-Lisa Clausen et al. – JAMA Dermatology – January 2018


Evidence that Human Skin Microbiome Dysbiosis Promotes Atopic Dermatitis – Michael R. Williams – Journal of Investigative Dermatology – December 2017

ReviewThe role of the skin microbiome in atopic dermatitis: a systematic review – R.D. Bjerre – British Journal of Dermatology – November 2017

The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls – Hans Christian Ring – JAMA Dermatology – September 2017

Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare – Kern Rei Chng – Nature Microbiology – July 2016

ReviewBacterial and Viral Infections in Atopic Dermatitis: a Comprehensive Review – Peck Y. Ong – Clinical Reviews in Allergy & Immunology – July 2016

ReviewIntegrative concepts of rosacea pathophysiology, clinical presentation, and new therapeutics – Anna D. Holmes -Experimental Dermatology – June 2016

Comprehensive pyrosequencing analysis of the bacterial microbiota of the skin of patients with seborrheic dermatitis – Akiomi Tanaka – Microbiology and Immunology – June 2016

Review: Skin Biomes (Topical Collection on Allergic Skin Diseases) – N. Fyhrquist – Current Allergy and Asthma Reports – May 2016

Review: The microbiome and atopic eczema: More than skin deep – Charlotte L Thomas – Australasian Journal of Dermatology – January 2016

Review: The skin microbiome: Associations between altered microbial communities and disease – Laura S Weyrich – Australasian Journal of Dermatology – February 2015

Review, Open AccessMicrobiota in Healthy Skin and in Atopic Eczema – Giuseppe Baviera – BioMed Research International – July 2014

Review, Open Access: Skin Microbiome and Skin Disease: The Example of Rosacea  –  Mauro Picardo, Monica Ottaviani – Journal of Clinical Gastroenterology – November 2014

Structure and function of the human skin microbiome – Nina N. Schommer, Richard L. Gallo – Trends in Microbiology – December 2013

Poster abstract: The skin microbiome in psoriatic arthritis: methodology development and pilot data – Madhura Castelino – The Lancet – 2015

Wound microbiology

Book chapter: The Microbiota of the Human Skin – Markus Egert – Microbiota of the Human Body – May 2016

Analysis of the chronic wound microbiota of 2,963 patients by 16S rDNA pyrosequencing –
Randall D. Wolcott – Wound Repair and Regeneration – January 2016

Influence of microbiome species in hard-to-heal wounds on disease severity and treatment duration – Dagmar Chudobova – The Brazilian Journal of Infectious Diseases – November 2015

ReviewBiofilms and Wounds: An Overview of the Evidence – Steven L. Percival – Adv Wound Care (New Rochelle) – July 2015

Biochemical Association of Metabolic Profile and Microbiome in Chronic Pressure Ulcer Wounds – Mary Cloud B. Ammons – PLOS ONE – May 2015

Prevalence and antibiotic susceptibility of bacteria from acute and chronic wounds in Malaysian subjects – Shin Yee Wong – The Journal of Infection in Developing Countries – 2015

ReviewBurn Wound Infections – Deirdre Church – Clinical Microbiology Reviews – April 2006

Popular press articles

How Much Does the Skin Microbiome Change Over Time? – Julia Oh – GOJO blog – July 2016

Microbes of the Skin: Human skin, the barrier between the body and the outside world, is home to diverse microorganisms, some of which can promote immunity or fight invaders – Jef Akst – The Scientist – June 13, 2014

Skin Microbes Alter Immunity: Like commensal gut organisms, skin microbiota appear to help the mammalian immune system mature and stay regulated – Edyta Zielinska – The Scientist – July 2012