General microbiology and science, June 10

Transcription in 12 different human tissues, bacteria in arterial plaques, and hairs with anticancer activity.

Infection and Host Response

Genome wideGenome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues – Zhiyun Guo – Nature Scientific Reports

“Finally, we describe TSmiR (, a novel and web-searchable database that houses interaction maps of TF-TS miRNA in 12 tissues.”

IntracellularIntracellular Bacteria Interfere with Dendritic Cell Functions: Role of the Type I Interferon Pathway – Laurent Gorvel – PLOS ONE

To analyze the mechanisms used by C. burnetiiand B. abortus to alter moDC activation, we performed microarray and found that C. burnetiiand B. abortus induced a specific signature consisting of TLR4TLR3STAT1 and interferon response genes.”

Screen Shot 2014-06-10 at 9.55.25 PMBacteria Present in Carotid Arterial Plaques Are Found as Biofilm Deposits Which May Contribute to Enhanced Risk of Plaque Rupture – Bernard B. Lanter – mBio

“In the current work, atherosclerotic carotid artery explants from 15 patients were all shown to test positive for the presence of eubacterial 16S rRNA genes”

Screen Shot 2014-06-10 at 10.01.00 PMRNA-seq: Impact of RNA degradation on transcript quantification – Irene Gallego Romero – BMC Biology

“We sought to quantify the impact of variation in RNA quality on estimates of gene expression levels based on RNA-seq data.”

Dengue virus

DengueSpatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas – Daiana Mir – PLOS ONE

“Our study reveals that genetic diversity of DENV-2 AS/AM genotype circulating in the Americas mainly resulted from one single founder event and can be organized in at least four major lineages”

Phages, viruses, CRISPRs

Screen Shot 2014-06-10 at 9.53.22 PMCasposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity – Mart Krupovic – BMC Biology

“We describe a new superfamily of archaeal and bacterial mobile elements which we denote casposons because they encode Cas1 endonuclease, a key enzyme of the CRISPR-Cas adaptive immunity systems of archaea and bacteria. “

Dr. Bik’s Picks

GeckoHow do geckos climb? – Ann Le Good – BioMedCentral

“The answer, from the recent Royal Society conference on cell adhesion, is that their climbing mechanism depends on van der Waals forces (as well as friction and shear stress). “

This one is intriguing:
AnticancerAnticancer Properties of Peptide Fragments of Hair Proteins – Sergiusz Markowicz – PLOS ONE

“We found out that the mixtures of soluble peptides obtained from human hair inhibited the proliferation of human melanoma cells in vitro. Moreover, the hair-derived peptide mixtures also inhibited the proliferation of B lymphoma cells and urinary bladder cancer cells. “

EarthEarth is around 60 million years older than previously thought — and so is the moon, new research finds – Science Daily

The timing of the giant impact between Earth’s ancestor and a planet-sized body occurred around 40 million years after the start of solar system formation. This means that the final stage of Earth’s formation is around 60 million years older than previously thought, according to new research.”



Human microbiome digest – May 28, 2014

Today I will have four separate posts, to see if that would work better. This post is all about the human microbiome, with articles about arthritis, childhood wheezing, and pregnancy.

Human Gut Microbiome

Screen shot 2014-05-28 at 06.03PM, May 28Human Respiratory Microbiome

Screen shot 2014-05-28 at 06.08PM, May 28Pregnancy and Birth