Human microbiome digest, October 6, 2014

Preterm birth, multiple sclerosis, aging, and Clostridium difficile infection in animal models.

Pregnancy and Birth

Necrotizing Enterocolitis: A Clinical Review on Diagnostic Biomarkers and the Role of the Intestinal Microbiota – Niemarkt, Hendrik J. – Inflammatory Bowel Diseases

“In this review, we discuss the pathogenesis, diagnosis, and treatment of NEC with a focus on the role of microbiota in the development of NEC.”

* Intestinal microbiota of preterm infants differ over time and between hospitals – Diana H Taft – Microbiome Journal

“DNA extracted from stool was used to sequence the 16S rRNA gene by Illumina MiSeq using universal primers. “

Babies’ Gut Bacteria Are Mostly Fixed By Time Spent In The Womb – Nicholas Ellaby – Science 2.0

“Now, a new study published in the journal Proceedings of the National Academy of Sciences has added a critical piece to the puzzle. “

Human Gut Microbiome

Gut microbiome and the risk factors in central nervous system autoimmunity – Javier Ochoa-Repárazemail, Lloyd H. Kasper – FEBS Letters

“Of interest to this review is the consistency between this range of MS risk factors and the gut microbiome. We postulate that the gut microbiome serves as the niche where different MS risk factors merge, thereby influencing the disease process.”

Compositional dynamics of the human intestinal microbiota with aging: Implications for health – B. Lakshminarayanan – The Journal of Nutrition, Health & Aging

“This review summarizes the age-related changes in the microbiota of the gastrointestinal tract (GIT) and the link between the gut microbiota in health and disease. “

Animal models of microbiome research

A Beneficial Effect of Oral Tigecycline Treatment on Clostridium difficile Infection in Gnotobiotic Piglets – Hyeun Bum Kim – Antimicrobial Agents and Chemotherapy

“The efficacy of oral tigecycline treatment (2mg/kg for 7 days) on Clostridium difficile infection (CDI) was evaluated in the gnotobiotic pig model, and its effect on human gut microflora transplanted into the gnotobiotic pig was determined. “

A novel multi-strain probiotic and synbiotic supplement for prevention of Clostridium difficile infection in a murine model – Kanthi Kiran Kondepudi – Microbiology and Immunology

“Feces and cecal contents were collected for microbial cell viability, quantitative PCR (qPCR), toxin analyses and histopathology.“

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