Tag Archives: virulence

December 04, 2025

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Human & Clinical Microbiome

Modifiable risk factors for inflammatory bowel disease in Kuwait – Reem Alhasan – PLOS ONE

Host–Pathogen Interactions (Human-focused)

Pharmacokinetic profiles of Moutan Cortex after single and repeated administration in a colitis model – Jin-Hwa Kim – PLOS ONE

ceRNA regulatory network and immune-neurodegenerative mechanisms of peripheral CD4+ T cells in Parkinson’s disease – Lijun Guo – PLOS ONE

Safety profile of TNF-α inhibitors in pediatric patients – Yanmo Yang – PLOS ONE

Animal Microbiome

Gut bacteria induce heterologous immune priming in Rhodnius prolixus – Carissa A Gilliland – PLOS Pathogens

A reliable in vitro rumen culture system for screening anti-methanogenic compounds – Philip P Laric – PLOS ONE

High-Resolution Melting assays for discrimination of fungal pathogens causing Grapevine Trunk Diseases – Filipe Azevedo-Nogueira – PLOS ONE

Bimodal expression of Type III Secretion System 2 enables cooperative virulence in Salmonella Typhimurium – Milada Pospíšilová – PLOS Pathogens

Animal Experiments (disease models)

The female reproductive tract–gut axis in gastrointestinal parasitic infection – Olivia Shorthouse – PLOS Pathogens

Toxoplasma gondii disrupts intestinal microbiota and host metabolism in rats – Ji-Xin Zhao – PLOS NTDs

Sarcopenia modelling by portal vein ligation inducing hyperammonemia in rats – Maria Nadinskaia – PLOS ONE

Evogliptin prevents ceramide-induced pyroptosis via NLRP3/GSDM-D pathway – Razia Rashid Rahil – PLOS ONE

Mechanistic insight into the antidiabetic effects of Ficus hispida fruits – Nusaiba Jahan – PLOS ONE

Computational Microbiology & Modeling

Identification of dynamic models of microbial communities – Ana Paredes-Vázquez – PLOS Computational Biology

Accuracy of the Lotka–Volterra model fails in strongly coupled microbial systems – Michael P Mustri – PLOS Computational Biology

Plant, Soil & Ecological Microbiome

Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function – Athena L Munden – PLOS Biology

Microbiome Digest, October 23, 2014

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Not much microbiome news today – which was good because I got time to watch the solar eclipse and a huge solar storm at the same time.  Enjoy the read!

Animal models of microbiome research

Lyn Deficiency Leads to Increased Microbiota-Dependent Intestinal Inflammation and Susceptibility to Enteric Pathogens – Morgan E. Roberts – Journal of Immunology

“Lyn2/2 mice exhibited profound cecal inflammation, bacterial dissemination, and morbidity following S. Typhimurium challenge and greater colonic inflammation throughout the course of C. rodentium infection.”

Rock microbiome

* Halophilic Archaea Cultivated from Surface Sterilized Middle-Late Eocene Rock Salt Are Polyploid – Salla T. Jaakkola – PLOS ONE

“We used real-time PCR to show that our isolates are polyploid, with genome copy numbers of 11–14 genomes per cell in exponential growth phase.”

More Microbiology

Zooming in to see the bigger picture: Microfluidic and nanofabrication tools to study bacteria – Felix J. H. Hol, Cees Dekker – Science

“Here, we review the new scientific insights gained by using a diverse set of nanofabrication and microfluidic techniques to study individual bacteria and multispecies communities.”

Review: Theory and Empiricism in Virulence Evolution – James J. Bull, Adam S. Lauring – PLOS Pathogens

“Our purpose here is to offer a brief introduction to virulence theory, explain some of its strengths and weaknesses, and suggest how theory might be united with empiric data”

Techniques

Comparing the new 16S rRNA V4 and ITS primers to the old primers-RESULTS! – Embriette Hyde – MicroBEnet

“The Knight lab has been working hard testing new primers for 16S rRNA amplicon production and its time to share our progress.”

Microbes in the News

As permafrost soils thaw, soil microbes amplify global climate change – Science Daily

“Now, research by an international team of scientists from the U.S., Sweden and Australia, led by University of Arizona scientists, shows that a single species of microbe, discovered only very recently, is an unexpected key player in climate change.”

* The Scientist: Prof. Esther Angert Studies Extreme Bacteria – Siddesh Ramesh – Cornell Sun

“While the majority of bacteria cannot be seen without a microscope, there exists a group of bacterial species that is visible to the naked eye. Known as Epulopiscium, they are “an extreme on the spectrum of diversity of bacterial life in existence,” according to Prof. Esther Angert, microbiology.”

Bik’s Picks

Flare Alert: Monster Sunspot Turns Toward Earth – Ian O’Neill – Discovery

“Amateur astronomers have been wowed by a vast sunspot that has rotated to face Earth, the largest since this solar cycle began in 2008, and solar observatories (on the ground and orbiting Earth) are closely monitoring the region.“

Watch cell division with new, remarkable resolution: Nobel winner Betzig strikes again – Tech Times

“Just weeks after sharing the Nobel Prize in chemistry for his work involving high-resolution microscopes, a U.S. researcher has again stunned the scientific world with a new technique that peers deeply into living cells.”

Ancient Europeans do not drink milk according to new study – BetaWired

“Almost everyone drinks milk today but a new study shows that ancient Europeans were not milk lovers back in the old days. According to a DNA analysis result, ancient Europeans are lactose intolerant.”

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