Today’s Microbiome Digest showcases a study of a microbiota derived metabolite that promotes HDAC3 in the gut indicating an epigenetic senror of the microbiota, as well as several interesting papers from Cell Host & Microbe, Nature Microbiology and mSystems.

Covid-19

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic – Boni et al. Nature Microbiology

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients – Wang et al. Cell Host & Microbe

General microbiome

The human gut archaeome: identification of diverse haloarchaea in Korean subjects – Kim et al. BMC Microbiome. 

Microbiota-derived metabolite promotes HDAC3 activity in the gut – Wu et al. Nature

Antibiotics

Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis – Bellerose et al. mSystems

Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis – Quigley et al. mBio

Water and extremophile microbiome

Microbial Metabolic Redundancy Is a Key Mechanism in a Sulfur-Rich Glacial Ecosystem – Trivedi et al. mSystems

Bioinformatics

Precise Species Identification for Enterobacter: a Genome Sequence-Based Study with Reporting of Two Novel Species, Enterobacter quasiroggenkampii sp. nov. and Enterobacter quasimori sp. Nov. – Wu et a. mSystems

Phages and viruses

Doubling of the known set of RNA viruses by metagenomic analysis of an aquatic virome – Wolf et al. Nature Microbiology