Human microbiome, July 9

Microbiome in pediatric Crohn’s disease patients, tipping elements in the human intestinal ecosystem, and oral microbes in the respiratory tract of carcinoma patients.

Gut microbiome

Crohn diseasePediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature – Yael Haberman – Journal of Clinical Investigation

“Here, we characterized the global pattern of ileal gene expression and the ileal microbial community in 359 treatment-naive pediatric patients with CD, patients with ulcerative colitis (UC), and control individuals. “

Tipping elementsTipping elements in the human intestinal ecosystem – Leo Lahti – Nature Communications

“Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify groups of bacteria that exhibit robust bistable abundance distributions. These bacteria are either abundant or nearly absent in most individuals, and exhibit decreased temporal stability at the intermediate abundance range. “

Respiratory microbiome

Detection and identification of oral anaerobes in intraoperative bronchial fluids of patients with pulmonary carcinoma – Ayako Hasegawa – Microbiology & Immunology

“This study aimed to quantify and identify bacteria in intraoperative bronchial fluids and to evaluate the relationship between impairment of cough/swallowing reflexes and silent aspiration of oral bacteria in elderly patients. “

A large genomic island allows Neisseria meningitidis to utilize propionic acid, with implications for colonization of the human nasopharynx – Maria Chiara E. Catenazzi – Microbiology & Immunology

“This genomic island is absent from the close relative of N. meningitidis, the commensal Neisseria lactamica, which chiefly colonizes infants not adults. “

Animal models of microbiome and disease

Microbiota-Driven Immune Cellular Maturation Is Essential for Antibody-Mediated Adaptive Immunity to Staphylococcus aureus Infection in the Eye – Tanweer Zaidi – Infection and Immunity

“ In germfree mice, there was no protective efficacy of antibody to PNAG due to the lack of LY6G+ inflammatory cell coeffector recruitment to the cornea.”


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