Human microbiome, June 16

A guide to your poop and more serious papers about oral, vaginal microbiomes and bacteria detection in joint fluids.

Oral microbiome

Screen Shot 2014-06-16 at 11.19.50 PMBacteria choose to fight and flee (commentary on a recent PNAS paper by Stacy et al. )- Christina Tobin Kåhrström – Nature Reviews Microbiology

“Together, these data suggest an elegant mechanism by which A. actinomycetemcomitans uses catalase to enzymatically ‘fight’ H2O2 and dispersin B to ‘flee’ from the close vicinity of S. gordonii, where H2O2 levels are highest, to a location where access to L-lactate is still possible. “

Oral challengesFornitersChallenges in the culture-independent analysis of oral and respiratory samples from intubated patients – Vladimir Lazarevic – Front. Cell. Infect. Microbiol.

“We explored the bacterial community diversity of the microbiota from oral and respiratory samples of intubated patients hospitalized in the intensive care unit and we discuss the technical challenges that may arise while using culture-independent approaches to study these types of samples.”

Vaginal microbiome

Ashok VagInfluence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections – Ashok Aiyar – Front. Cell. Infect. Microbiol.

“In this review, we discuss the natural history of genital chlamydial infections, morphological and molecular changes imposed by IFNγ on Chlamydia, and finally, the microenvironmental conditions associated with vaginal co-infections that can ameliorate the effects of IFNγ on C. trachomatis.”

Gut microbiome

ToiletThe Not-So-Gross Guide to Your Poop – Laura Barcella – Refinery29

“So, what is your excrement trying to tell you? Read on for clues about how to decipher your bowel movements.”

Bacteria detection in otherwise sterile sites

Screen Shot 2014-06-16 at 11.24.38 PMRapid isolation and diagnosis of live bacteria from human joint fluids by using an integrated microfluidic system – Wen-Hsin Chang – Lab on a Chip


“…an integrated microfluidic system capable of detecting live bacteria from clinical PJI samples within 55 minutes is developed in this study. This system employs an ethidium monoazide (EMA)-based assay and a PCR with universal bacterial primers and probes to isolate and detect only the live bacteria that commonly cause PJI. “