March 1st, 2021

God morgon!

Good morning from Sweden. It is hard to believe that it has been a year since the unprecedented happenings of March 2020 but regardless of how we see it, time flies!

The most interesting read of the day is a study that conclusively proves that the oral microbiota is not influenced by your genetics, but by environmental factors. I was intrigued by the use of a video byte, a small video abstract of the paper, which is something new for me. In my opinion, it could very well be the next big thing in academic publishing as it took me just two minutes to understand the whole study! Do check it out!

A promising study is in a preprint where the researchers show that the pre-colonization with a less virulent strain of Clostridioides difficile protects model organisms from subsequent lethal colonization of C. difficile. This has important therapeutic implications in case of nosocomial, antibiotic-promoted diarrhea. Another exciting study shows the influence of gut microbiome on colorectal cancer. The researchers showed that the transplant of ‘good’ microbiota from healthy donors could even reduce the tumorigenesis in the disease models.

Elsewhere in the digest are studies on microbiome of tropical marine sediments, novel proteins from human intestinal microbiome, virulence factors of Trypanosoma brucei, and new therapeutic epitopes in N1 neuraminidase of Influenza virus.

Happy reading!

Bacteria Hysteria

Preprint: Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant – Jhansi L. Leslie, et al.

Preprint: Fiber-associated Lachnospiraceae reduce colon tumorigenesis by modulation of the tumor-immune microenvironment – Ana S Almeida, et al.

Preprint: G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival – Praveen Prakhar, et al.

Preprint: Identification of a chromosomally-encoded sucrose operon-like gene cluster in Vibrio parahaemolyticus strain PH05 isolated from Negros Island, Philippines – Czarina Anne E. De Mesa, et al.

Preprint: Gene flux and acid-imposed selection are the main drivers of antimicrobial resistance in broiler chicks infected with Salmonella enterica serovar Heidelberg – Adelumola Oladeine, et al.

Preprint: Analyses of the complete genome sequence of 2,6-dichlorobenzamide (BAM) degrader Aminobacter sp. MSH1 suggests a polyploid chromosome, phylogenetic reassignment, and functions of (un)stable plasmids – Tue Kjærgaard Nielsen, et al.

Preprint: Growth response and recovery of Corynebacterium glutamicum colonies on single-cell level upon defined pH stress pulses – Sarah Täuber, et al.

Preprint: Comparative genomics analysis of Chryseobacterium sp. KMC2 reveals metabolic pathways involved in keratinous utilization and natural product biosynthesis – Dingrong Kang, et al.

Preprint: Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum – Danielle M. Vermilyea, et al.

General Microbiome

Acquisition of oral microbiota is driven by environment, not host genetics – Chiranjit Mukherjee, et al., Microbiome

Dicer-like proteins influence Arabidopsis root microbiota independent of RNA-directed DNA methylation – Richa Kaushal, et al., Microbiome

The bacterial communities of Alaskan mosses and their contributions to N2-fixation – Hannah Holland-Moritz, et al., Microbiome

Preprint: A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria – Sofiene Seef, et al.

Preprint: Completion of the gut microbial epi-bile acid pathway – Heidi L. Doden, et al.

Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome – Hannes Petruschke, et al., Microbiome

Metagenomics and Bioinformatics

Preprint: Beyond taxonomic identification: integration of ecological responses to a soil bacterial 16S rRNA gene database – Briony A. Jones, et al.

Preprint: Amplicon sequence variants artificially split bacterial genomes into separate clusters – Patrick D. Schloss

Preprint: Microbial diversity in tropical marine sediments assessed using culture-dependent and culture-independent techniques – Alyssa M Demko, Nastassia V Patin, and Paul R. Jensen.


Preprint: The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication – JInlin Li, et al.

Preprint: Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase – Ericka Kirkpatrick Roubidoux, et al.


Preprint: Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence – Mariana De Niz, et al.

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