August 24th, 2020

God morgon!

Good morning from Sweden.

I am sure there are a lot of labs and scientists with interesting therapeutic options against COVID19, but unable to do so due to lack of BSL-3 facilities. Good news for them as today’s digest carries a preprint where some researchers show that a recombinant vesicular stomatitis virus expressing nCoV spike protein can be used to evaluate the potential of anti-spike antibodies. They designed a specific assay which could be modified to work out for evaluation of other therapeutics. Continuing with viruses, there is another preprint that delineates a new strategy to design effective vaccines against Ebola virus.

New research published in Microbiome journal describes the effect of antimicrobials on salivary microbiota and how gut microbiota may be implicated in regulating autism-like behaviour through vitamin B6 homoeostasis.

Elsewhere in the digest is new research featuring a new technique ‘Protoblock’ for increasing reproducibility in pathology samples, biocontrol of plant disease using bacteria, on-site detection of Genus Clavibacter, and the basis of cell polarity in bacteria.

Happy reading and have a great week!

Preprint: Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein – Hideki Tani, et al.

Antimicrobial drug use in the first decade of life influences saliva microbiota diversity and composition – Sajan C. Raju, et al, Microbiome

The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice – Ying Li, et al, Microbiome

Preprint: Scaffold-scaffold interactions regulate cell polarity in a bacterium – Wei Zhao, et al.

Preprint: Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines – Linling He, et al.

Preprint: Multiplex recombinase polymerase amplification (RPA) assay developed using unique genomic regions and coupled with a lateral flow device for rapid on-site detection of genus Clavibacter and C. nebraskensis – Adriana Larrea-Sarmiento, et al.

Preprint: Evaluation of the efficacy of some PGPR bacteria in controlling Fusarium wilt disease Fusarium oxysporum f.sp. lycopersici on the tomato plant – Halima Z Hussein and Shaker I Al-Dulaimi.

Preprint: Mutually Beneficial Symbiosis Between Human and Gut-Dominant Bacteroides Species Through Bacterial Assimilation of Host Mucosubstances – Masahiro Sato

Protoblock – A biological standard for formalin fixed samples – Yensi Flores Bueso, et al, Microbiome

Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate – Nguyen K. Nguyen, et al, Microbiome

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